Expression of parathyroid hormone-related protein and the parathyroid hormone/parathyroid hormone-related protein receptor in rat thymic epithelial cells

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Expression of parathyroid hormone-related protein and the parathyroid hormone/parathyroid hormone-related protein receptor in rat thymic epithelial cells.

Thymic epithelial cells are an important source of cytokines and other regulatory peptides which guide thymocyte proliferation and maturation. Parathyroid hormone-related protein (PTHrP), a cytokine-like peptide, has been reported to affect the proliferation of lymphocytes in vitro. The studies presented here were undertaken to test the hypotheses that PTHrP is produced locally within the thymu...

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Parathyroid hormone-related protein in teleost fish.

A brief description is given of the discovery of PTHrP and the roles of the peptide in mammalian physiology. Next, the occurrence of PTHrP in the earliest vertebrates, sharks, skates and fishes, is reviewed and the calciotropic functions of PTHrP are addressed more specifically in fishes. Parathyroid hormone-related protein (PTHrP) is a hypercalcemic hormone in teleostean fishes, but also has p...

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Parathyroid hormone-related protein promotes epithelial-mesenchymal transition.

Epithelial-mesenchymal transition (EMT) is an important process that contributes to renal fibrogenesis. TGF-beta1 and EGF stimulate EMT. Recent studies suggested that parathyroid hormone-related protein (PTHrP) promotes fibrogenesis in the damaged kidney, apparently dependent on its interaction with vascular endothelial growth factor (VEGF), but whether it also interacts with TGF-beta and EGF t...

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Chapter 26. Parathyroid Hormone-Related Protein

19. Brown EM, MacLeod RJ 2001 Extracellular calcium sensing and extracellular calcium signaling. Physiol Rev 81:239-297. 20. Chang W, Chen TH, Pratt S, Shoback D 2000 Amino acids in the second and third intracellular loops of the parathyroid Ca2+sensing receptor mediate efficient coupling to phospholipase C. J Biol Chem 27519955-19963. 21. Pearce SH, Williamson C, Kifor 0, Bai M, Coulthard MG, ...

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Parathyroid Hormone-Related Protein Stimulates Plasma Renin

21 22 Corresponding author: 23 Prof. William H. Beierwaltes, Ph.D. 24 Senior Research Scientist, 25 Dept. Internal Medicine, 26 Hypertension and Vascular Research Div., 27 Henry Ford Hospital 28 7121 E&R Bldg., 2799 W. Grand Blvd., Detroit, MI 48202 29 313-916-7494, FAX 313-916-5284, [email protected] 30 31 32 33 34 35 Articles in PresS. Am J Physiol Endocrinol Metab (May 29, 2012). doi:10.1152...

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ژورنال

عنوان ژورنال: Journal of Anatomy

سال: 1999

ISSN: 0021-8782,1469-7580

DOI: 10.1046/j.1469-7580.1999.19420255.x